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Version: 17.06d (Release date: 2017-06-26)
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Oleandrin (Code C90586)

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Terms & Properties

Preferred Name: Oleandrin

Definition: A lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically binds to and inhibits the alpha3 subunit of the Na/K-ATPase pump in human cancer cells. This may inhibit the phosphorylation of Akt, upregulate MAPK, inhibit NF-kb activation and inhibit FGF-2 export and may downregulate mTOR thereby inhibiting p70S6K and S6 protein expression. All of this may lead to an induction of apoptosis. As cancer cells with relatively higher expression of the alpha3 subunit and with limited expression of the alpha1 subunit are more sensitive to oleandrin, one may predict the tumor response to treatment with lipid-soluble cardiac glycosides such as oleandrin based on the tumors Na/K-ATPase pump protein subunit expression. Overexpression of the alpha3 subunit in tumor cells correlates with tumor proliferation.

Display Name: Oleandrin

Label: Oleandrin

NCI Thesaurus Code: C90586 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0069397  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oleandrin
PBI-05204

External Source Codes: 
ChEBI ID CHEBI:59030 (see ChEBI info)
PDQ Closed Trial Search ID 579304
PDQ Open Trial Search ID 579304 (check for NCI PDQ open clinical trial info)
UMLS CUI C0069397

Other Properties:
     Name Value (qualifiers indented underneath)
code C90586
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90586

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