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Version: 17.06d (Release date: 2017-06-26)
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Orteronel (Code C90582)

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Terms & Properties

Preferred Name: Orteronel

Definition: An orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones, such as progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.

Display Name: Orteronel

Label: Orteronel

NCI Thesaurus Code: C90582 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2983781  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-((7S)-7-hydroxy-6,7-dihydro-5h-pyrrolo(1,2-c)imidazol-7-yl)-N-methyl-2-naphthalenecarboxamide
Androgen Synthesis Inhibitor TAK-700
CYP17A1 Lyase Inhibitor TAK-700
Orteronel
ORTERONEL
TAK-700

External Source Codes: 
CAS Registry Number 566939-85-3 (see NLM ChemIDplus info)
FDA UNII Code UE5K2FNS92
PDQ Closed Trial Search ID 583018
PDQ Open Trial Search ID 583018 (check for NCI PDQ open clinical trial info)
UMLS CUI C2983781

Other Properties:
     Name Value (qualifiers indented underneath)
code C90582
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90582

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