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Version: 17.06d (Release date: 2017-06-26)
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Akt Inhibitor MK2206 (Code C90581)

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Terms & Properties

Preferred Name: Akt Inhibitor MK2206

Definition: An orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

NCI-GLOSS Definition: An orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents

Display Name: Akt Inhibitor MK2206

Label: Akt Inhibitor MK2206

NCI Thesaurus Code: C90581 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2933427  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Akt Inhibitor MK2206
Akt inhibitor MK2206
MK2206

External Source Codes: 
PDQ Closed Trial Search ID 596332
PDQ Open Trial Search ID 596332 (check for NCI PDQ open clinical trial info)
UMLS CUI C2933427

Other Properties:
     Name Value (qualifiers indented underneath)
code C90581
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90581

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