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Version: 17.06d (Release date: 2017-06-26)
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Zirconium Zr 89 Trastuzumab (Code C90575)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Zirconium Zr 89 Trastuzumab

Definition: A radioimmunoconjugate containing the recombinant humanized monoclonal antibody trastuzumab labeled with the radioisotope zirconium Zr 89 with radioisotopic activity and potential use as an imaging agent. The trastuzumab moiety of zirconium Zr 89 trastuzumab binds with high affinity to the extracellular domain of human epidermal growth factor receptor 2 (HER2). Upon binding, the radioisotope moiety may be detected using positron emission tomography (PET), thereby allowing the imaging and quantification of HER2-expressing tumor cells. HER2, a tyrosine kinase client protein of heat shock protein 90 (Hsp90), may be overexpressed on the cell surfaces of various tumor cell types.

Display Name: Zirconium Zr 89 Trastuzumab

Label: Zirconium Zr 89 Trastuzumab

NCI Thesaurus Code: C90575 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2983775  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
89Zr-Trastuzumab
Zirconium Zr 89 Trastuzumab

External Source Codes: 
PDQ Closed Trial Search ID 667938
PDQ Open Trial Search ID 667938 (check for NCI PDQ open clinical trial info)
UMLS CUI C2983775

Other Properties:
     Name Value (qualifiers indented underneath)
code C90575
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90575

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