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Version: 16.11d (Release date: 2016-11-28)
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IAP Inhibitor AT-406 (Code C90574)

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Terms & Properties

Preferred Name: IAP Inhibitor AT-406

Definition: An orally bioavailable inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins with potential apoptotic inducing and antineoplastic activity. IAP inhibitor AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP). This may restore and promote the induction of apoptosis through apoptotic signaling pathways. AT-406 may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains.

Display Name: IAP Inhibitor AT-406

Label: IAP Inhibitor AT-406

NCI Thesaurus Code: C90574 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3177416  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AT-406
IAP Inhibitor AT-406
Pyrrolo(1,2-a)(1,5)diazocine-8-carboxamide, n-((1,1'-biphenyl)-2-ylmethyl)decahydro-5-(((2s)-2-(methylamino)-1-oxopropyl)amino)-3-(3-methyl-1-oxobutyl)-6-oxo-, (5s,8s,10ar)
SM-406

External Source Codes: 
FDA UNII Code N65WC8PXDD
PDQ Closed Trial Search ID 667935
PDQ Open Trial Search ID 667935 (check for NCI PDQ open clinical trial info)
UMLS CUI C3177416

Other Properties:
Name Value (qualifiers indented underneath)
code C90574
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90574

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