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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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JAK2 Inhibitor XL019 (Code C90573)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: JAK2 Inhibitor XL019

Definition: An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. XL019 inhibits the activation of JAK2 as well as the mutated form JAK2V617F, which may result in the inhibition of the JAK-STAT signaling pathway and may induce apoptosis. The JAK2 mutated form JAK2V617F has a valine-to-phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival.

Display Name: JAK2 Inhibitor XL019

Label: JAK2 Inhibitor XL019

NCI Thesaurus Code: C90573 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416257  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
JAK2 Inhibitor XL019
XL019

External Source Codes: 
PDQ Closed Trial Search ID 667451
PDQ Open Trial Search ID 667451 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416257

Other Properties:
     Name Value (qualifiers indented underneath)
code C90573
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90573

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