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Version: 17.12d (Release date: 2017-12-26)
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Capmatinib (Code C90564)

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Terms & Properties

Preferred Name: Capmatinib

Definition: An orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. Capmatinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

Display Name: Capmatinib

Label: Capmatinib

NCI Thesaurus Code: C90564 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416248  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
Capmatinib
CAPMATINIB
INC-280
INC280
INCB 28060
INCB028060
INCB28060

External Source Codes: 
CAS Registry Number 1029712-80-8 (see NLM ChemIDplus info)
FDA UNII Code TY34L4F9OZ
PDQ Closed Trial Search ID 666907
PDQ Open Trial Search ID 666907 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416248

Other Properties:
     Name Value (qualifiers indented underneath)
code C90564
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C90564

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