skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Capmatinib (Code C90564)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Capmatinib

Definition: An orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. Capmatinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

Display Name: Capmatinib

Label: Capmatinib

NCI Thesaurus Code: C90564 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416248  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
Capmatinib
INC280
INCB028060

External Source Codes: 
CAS Registry Number 1029712-80-8 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 666907
PDQ Open Trial Search ID 666907 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416248

Other Properties:
     Name Value (qualifiers indented underneath)
code C90564
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90564

Mainbox Bottom