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Version: 17.06d (Release date: 2017-06-26)
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Oncolytic HSV-1 rRp450 (Code C90563)

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Terms & Properties

Preferred Name: Oncolytic HSV-1 rRp450

Definition: A gene therapy agent containing an attenuated, replication-competent, genetically engineered mutant form of the Herpes simplex virus 1 (HSV-1) strain KOS with potential antineoplastic activity. Upon infusion into the hepatic artery, oncolytic HSV-1 rRp450 replicates in hepatocellular carcinoma (HCC) cells and exerts direct cytotoxic effects eventually disrupting cancer cell membranes and liberating progeny virions thereby infecting adjacent tumor cells. In addition, rRp450 expresses the cytochrome P450 transgene that activates oxazaphosphorines, such as cyclophosphamide (CPA). Therefore, CPA can become activated in the presence of rRp450 and exert its antineoplastic effect. rRp450 is deleted for the HSV-1 gene UL39, encoding the viral ribonucleotide reductase large subunit infected cell protein 6 (ICP6), thereby disrupting the activity of viral ribonucleotide reductase and resulting in the inhibition of nucleotide metabolism and viral DNA synthesis in nondividing cells but not in dividing cells. UL39 is replaced by the rat CYP2B1 gene, encoding a cytochrome P450 enzyme that activates oxazaphosphorines. rRp450 also expresses viral thymidine kinase, which activates the cancer prodrug ganciclovir.

Display Name: Oncolytic HSV-1 rRp450

Label: Oncolytic HSV-1 rRp450

NCI Thesaurus Code: C90563 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416247  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oncolytic HSV-1 rRp450

External Source Codes: 
PDQ Closed Trial Search ID 666906
PDQ Open Trial Search ID 666906 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C90563
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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