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Version: 17.06d (Release date: 2017-06-26)
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Antibody-like CD95 Receptor/Fc-fusion Protein CAN-008 (Code C90562)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Antibody-like CD95 Receptor/Fc-fusion Protein CAN-008

Definition: A human, soluble fusion protein consisting of the extracellular domain of the CD95 receptor fused to the Fc-domain of the human IgG antibody, with potential antineoplastic activity. Upon administration, antibody-like CD95 receptor/Fc-fusion protein CAN-008 binds to the CD95 ligand (CD95L) and blocks the binding of CD95L to the CD95 receptor. In tumor cells, blockage of CD95L-mediated signaling pathways may prevent cell migration and invasive cell growth; in healthy cells, blockage of CD95L-mediated signaling pathways may prevent apoptosis and may protect cell damage. Activation of the CD95 receptor plays an important role in the initiation of apoptosis in healthy cells or the invasive growth of cancer cells.

Label: Antibody-like CD95 Receptor/Fc-fusion Protein CAN-008

NCI Thesaurus Code: C90562 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2983762  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Antibody-like CD95 Receptor/Fc-fusion Protein CAN-008
APG-101
APG101
CAN-008
CAN008
CD95-Fc Fusion Protein CAN008
Fas-Fc Fusion Protein CAN008

External Source Codes: 
PDQ Closed Trial Search ID 666905
PDQ Open Trial Search ID 666905 (check for NCI PDQ open clinical trial info)
UMLS CUI C2983762

Other Properties:
     Name Value (qualifiers indented underneath)
code C90562
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90562

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