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Version: 16.11d (Release date: 2016-11-28)
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NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL (Code C90559)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL

Definition: Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 reactive TCR-transduced autologous PBLs bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for NY-ESO-1:157-165.

Display Name: NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL

Label: NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL

NCI Thesaurus Code: C90559 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416243  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-NY-ESO-1 TCR Retroviral Vector Transduced Autologous PBL
NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL

External Source Codes: 
PDQ Closed Trial Search ID 666521
PDQ Open Trial Search ID 666521 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416243

Other Properties:
Name Value (qualifiers indented underneath)
code C90559
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90559

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