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Version: 16.10e (Release date: 2016-10-31)
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Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205 (Code C90557)

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Terms & Properties

Preferred Name: Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205

Definition: A small-molecule inhibitor of the human kinesin-related motor protein Eg5 with potential antineoplastic activity. Eg5 kinesin-related motor protein inhibitor 4SC-205 selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein essential for the regulation of spindle dynamics, including assembly and maintenance, during mitosis.

Label: Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205

NCI Thesaurus Code: C90557 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416241  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205
Eg5 Kinesin Inhibitor 4SC-205
SC-205

External Source Codes: 
PDQ Closed Trial Search ID 666188
PDQ Open Trial Search ID 666188 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416241

Other Properties:
Name Value (qualifiers indented underneath)
code C90557
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90557

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