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Version: 17.06d (Release date: 2017-06-26)
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Carbon C 14 Ombrabulin (Code C90556)

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Terms & Properties

Preferred Name: Carbon C 14 Ombrabulin

Definition: A synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), labeled with carbon C 14 with potential antineoplastic activity. The ombrabulin moiety of carbon C 14 ombrabulin binds to the colchicine binding site of endothelial cell tubulin, thereby inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse; the acute disruption of tumor blood flow may result in tumor necrosis. The radioisotope moiety of this agent acts as a radioactive tracer.

Label: Carbon C 14 Ombrabulin

NCI Thesaurus Code: C90556 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416240  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Carbon C 14 Ombrabulin

External Source Codes: 
PDQ Closed Trial Search ID 666187
PDQ Open Trial Search ID 666187 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C90556
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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