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Version: 16.11d (Release date: 2016-11-28)
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CEA/Tetanus Toxoid T Helper Epitope Fusion Protein-Expressing DNA Plasmid Vaccine (Code C90555)

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Terms & Properties

Preferred Name: CEA/Tetanus Toxoid T Helper Epitope Fusion Protein-Expressing DNA Plasmid Vaccine

Definition: A plasmid vaccine encoding wild type human carcinoembryonic antigen (CEA) fused to a tetanus toxoid T helper epitope, with potential antineoplastic activity. Upon vaccination and subsequent intradermal electroporation, CEA/tetanus toxoid T helper epitope fusion protein-expressing DNA plasmid vaccine may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. CEA, a tumor associated antigen, is overexpressed in a variety of cancer cell types. The tetanus toxoid helper peptide epitope, obtained from the bacterial Clostridium tetani toxoid, binds to class II MHC molecules and increases the helper T-cell response thereby inducing an increased and long-term immune response.

Label: CEA/Tetanus Toxoid T Helper Epitope Fusion Protein-Expressing DNA Plasmid Vaccine

NCI Thesaurus Code: C90555 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416239  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CEA/Tetanus Toxoid T Helper Epitope Fusion Protein-Expressing DNA Plasmid Vaccine
tetwtCEA DNA

External Source Codes: 
PDQ Closed Trial Search ID 666096
PDQ Open Trial Search ID 666096 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416239

Other Properties:
Name Value (qualifiers indented underneath)
code C90555
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90555

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