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Version: 17.12d (Release date: 2017-12-26)
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bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine (Code C90552)

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Terms & Properties

Preferred Name: bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine

Definition: Autologous tumor cells transfected with a plasmid expressing recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) and bifunctional short hairpin RNA (bi-shRNA) against furin, with potential immunostimulatory and antineoplastic activities. Upon intradermal vaccination of bi-shRNA-furin/GM-CSF-expressing autologous tumor cell vaccine, expressed GM-CSF protein, a potent stimulator of the immune system, recruits immune effectors to the site of injection and promotes antigen presentation. The furin bifunctional shRNA blocks furin protein production. Decreased levels of furin lead to a reduction in the conversion of transforming growth factor (TGF) beta into TGF beta1 and beta2 protein isoforms. In turn, as part of the negative feedback mechanism, reduced furin protein levels inhibit TGFbeta1 and TGFbeta2 gene expression, thereby further decreasing TGF levels. As TGFs are potent immunosuppressive cytokines, reducing their levels may activate the immune system locally and this may eventually cause a cytotoxic T-lymphocyte (CTL) response against the tumor cells.

Display Name: bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine

Label: bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine

NCI Thesaurus Code: C90552 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2983751  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
bi-shRNA-Furin and Granulocyte Macrophage Colony Stimulating Factor Augmented Autologous Tumor Cell Vaccine
bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine
FANG Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 666077
PDQ Open Trial Search ID 666077 (check for NCI PDQ open clinical trial info)
UMLS CUI C2983751

Other Properties:
     Name Value (qualifiers indented underneath)
code C90552
Contributing_Source CTRP
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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