skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Sapanisertib (Code C90548)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sapanisertib

Definition: An orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Sapanisertib binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.

Display Name: Sapanisertib

Label: Sapanisertib

NCI Thesaurus Code: C90548 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2983747  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
INK-128
INK128
MLN-0128
MLN0128
Sapanisertib
SAPANISERTIB
TAK-228

External Source Codes: 
CAS Registry Number 1224844-38-5 (see NLM ChemIDplus info)
FDA UNII Code JGH0DF1U03
PDQ Closed Trial Search ID 665687
PDQ Open Trial Search ID 665687 (check for NCI PDQ open clinical trial info)
UMLS CUI C2983747

Other Properties:
     Name Value (qualifiers indented underneath)
code C90548
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90548

Mainbox Bottom