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Version: 17.06d (Release date: 2017-06-26)
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Lactoferrin-derived Lytic Peptide LTX-315 (Code C90547)

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Terms & Properties

Preferred Name: Lactoferrin-derived Lytic Peptide LTX-315

Definition: A peptide derived from human lactoferrin, with potential lytic and immunostimulating activities. Upon transdermal injection directly into the tumor, LTX315 may bind to the tumor cell membranes and subsequently lyse tumor cells, thereby inducing tumor cell necrosis. In turn, presentation of the tumor antigens to the immune system may induce systemic innate and adaptive immune responses mediated by anti-tumor natural killer (NK) cells, cytotoxic T lymphocytes, and natural killer T (NKT) cells. This may trigger an immune response against tumor associated antigens on tumors distant from the primary tumor. Human lactoferrin, a 692 amino acid glycoprotein, belongs to the transferrin family of metal-binding proteins.

Label: Lactoferrin-derived Lytic Peptide LTX-315

NCI Thesaurus Code: C90547 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416231  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Lactoferrin-derived Lytic Peptide LTX-315
LTX-315
Oncopore

External Source Codes: 
PDQ Closed Trial Search ID 665662
PDQ Open Trial Search ID 665662 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416231

Other Properties:
     Name Value (qualifiers indented underneath)
code C90547
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90547

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