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Version: 17.06d (Release date: 2017-06-26)
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L19-IL2 Monoclonal Antibody-Cytokine Fusion Protein (Code C90546)

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Terms & Properties

Preferred Name: L19-IL2 Monoclonal Antibody-Cytokine Fusion Protein

Definition: An immunoconjugate consisting of the recombinant form of the cytokine interleukin-2 (IL-2) fused to a human single-chain Fv (scFv) antibody fragment directed against the extra-domain B (ED-B) of fibronectin (L19), with potential immunopotentiating and antineoplastic activities. The L19 moiety of L19-IL2 monoclonal antibody-cytokine fusion protein binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. In turn, the IL-2 moiety may locally activate natural killer (NK) cells and macrophages, and may induce T cell cytotoxic immune responses against ED-B fibronectin-expressing tumor cells. This may specifically decrease the proliferation of ED-B-expressing tumor cells. ED-B is predominantly expressed during angiogenesis and tumor growth.

Label: L19-IL2 Monoclonal Antibody-Cytokine Fusion Protein

NCI Thesaurus Code: C90546 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416230  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L19-IL2
L19-IL2 Monoclonal Antibody-Cytokine Fusion Protein

External Source Codes: 
PDQ Closed Trial Search ID 665656
PDQ Open Trial Search ID 665656 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416230

Other Properties:
     Name Value (qualifiers indented underneath)
code C90546
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90546

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