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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Fluorouracil Implant (Code C90544)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorouracil Implant

Definition: An implant containing a sustained release particle of fluorouracil, an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine, with antineoplastic activity. Upon implantation and subsequent release, fluorouracil is converted into the active metabolite 5-fluoroxyuridine monophosphate that competes with the pyrimidine uracil during RNA synthesis while another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate, inhibits thymidylate synthase and thus DNA synthesis.

Label: Fluorouracil Implant

NCI Thesaurus Code: C90544 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416225  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fluorouracil Implant

External Source Codes: 
PDQ Closed Trial Search ID 665364
PDQ Open Trial Search ID 665364 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C90544
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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