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Version: 17.06d (Release date: 2017-06-26)
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Adenovirus-p53 Transduced Dendritic Cell Vaccine (Code C90542)

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Terms & Properties

Preferred Name: Adenovirus-p53 Transduced Dendritic Cell Vaccine

Definition: A cancer vaccine consisting of autologous dendritic cells (DCs) transduced with a recombinant adenovirus encoding p53 peptide, with potential immunomodulating activity. Intradermal vaccination with adenoviral-p53 transduced dendritic cell vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing mutant p53, resulting in tumor cell lysis. p53, a tumor suppressor gene, is mutated in many tumor cells, resulting in the loss of apoptosis regulation and abnormal cell proliferation.

Display Name: Adenovirus-p53 Transduced Dendritic Cell Vaccine

Label: Adenovirus-p53 Transduced Dendritic Cell Vaccine

NCI Thesaurus Code: C90542 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416223  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adenovirus-p53 Transduced Dendritic Cell Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 664347
PDQ Open Trial Search ID 664347 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416223

Other Properties:
     Name Value (qualifiers indented underneath)
code C90542
Contributing_Source CTRP
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90542

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