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Version: 16.10e (Release date: 2016-10-31)
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DM-CHOC-PEN (Code C90539)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: DM-CHOC-PEN

Definition: A cholesterol carbonate derivative of 4-demethylpenclomedine (DM-PEN) with potential antineoplastic alkylating activity. Upon intravenous administration of 4-demethylcholesteryloxycarbonylpenclomedine, the carbonium moiety binds to and alkylates DNA at the N7 guanine position, thereby causing DNA crosslinks. This prevents DNA replication, inhibits cellular proliferation and triggers apoptosis. In addition, due to its lipophilic cholesteryl moiety this agent is able to cross the blood brain barrier (BBB) and therefore can be given intravenously compared to other alkylating agents that need to be given intra-cranially.

Label: DM-CHOC-PEN

NCI Thesaurus Code: C90539 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416220  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Demethylcholesteryloxycarbonylpenclomedine
DM-CHOC-PEN

External Source Codes: 
PDQ Closed Trial Search ID 664344
PDQ Open Trial Search ID 664344 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416220

Other Properties:
Name Value (qualifiers indented underneath)
code C90539
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90539

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