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Version: 17.06d (Release date: 2017-06-26)
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TLR9 Agonist EMD 1201081 (Code C90533)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: TLR9 Agonist EMD 1201081

Definition: A synthetic oligonucleotide containing phosphorothioate oligodeoxynucleotide with potential immunopotentiating activity. TLR9 agonist EMD 1201081 binds to and activates the intracellular Toll-like receptor (TLR) 9 in monocytes/macrophages, plasmacytoid dendritic cells (DCs) and B cells, initiating immune signaling pathways, activating B cells and inducing T-helper cell cytokine production. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.

Display Name: TLR9 Agonist EMD 1201081

Label: TLR9 Agonist EMD 1201081

NCI Thesaurus Code: C90533 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2983728  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EMD 1201081
TLR9 Agonist EMD 1201081
Toll-like Receptor 9 Agonist EMD 1201081

External Source Codes: 
PDQ Closed Trial Search ID 663439
PDQ Open Trial Search ID 663439 (check for NCI PDQ open clinical trial info)
UMLS CUI C2983728

Other Properties:
     Name Value (qualifiers indented underneath)
code C90533
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90533

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