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Version: 16.11d (Release date: 2016-11-28)
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Ensituximab (Code C90532)

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Terms & Properties

Preferred Name: Ensituximab

Definition: A chimeric monoclonal antibody against human colorectal and pancreatic carcinoma-associated antigens (CPAAs) with potential immunomodulating and anti-tumor activities. Anti-CPAA monoclonal antibody NPC-1C binds to CPAAs, which may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response and an antibody-dependent cellular cytotoxicity (ADCC) response against CPAA-expressing tumor cells. CPAAs, cell surface proteins, are upregulated on colon and pancreatic tumor cells. NPC-1C contains the variable region of the heavy and light chain of murine NPC-1 and linked in-frame to constant regions of a human IgG1 isotype.

Display Name: Ensituximab

Label: Ensituximab

NCI Thesaurus Code: C90532 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413613  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-Colorectal and Pancreatic Carcinoma-Associated Antigen Monoclonal Antibody NPC-1C
Anti-CPAA Monoclonal Antibody NPC-1C
Ensituximab
ENSITUXIMAB
NPC-1C

External Source Codes: 
CAS Registry Number 1092658-06-4 (see NLM ChemIDplus info)
FDA UNII Code F988K568V2
PDQ Closed Trial Search ID 663436
PDQ Open Trial Search ID 663436 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413613

Other Properties:
Name Value (qualifiers indented underneath)
code C90532
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90532

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