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Version: 17.12d (Release date: 2017-12-26)
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Ensituximab (Code C90532)

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Terms & Properties

Preferred Name: Ensituximab

Definition: A chimeric monoclonal antibody against human colorectal and pancreatic carcinoma-associated antigens (CPAAs) with potential immunomodulating and anti-tumor activities. Anti-CPAA monoclonal antibody NPC-1C binds to CPAAs, which may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response and an antibody-dependent cellular cytotoxicity (ADCC) response against CPAA-expressing tumor cells. CPAAs, cell surface proteins, are upregulated on colon and pancreatic tumor cells. NPC-1C contains the variable region of the heavy and light chain of murine NPC-1 and linked in-frame to constant regions of a human IgG1 isotype.

Display Name: Ensituximab

Label: Ensituximab

NCI Thesaurus Code: C90532 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413613  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-Colorectal and Pancreatic Carcinoma-Associated Antigen Monoclonal Antibody NPC-1C
Anti-CPAA Monoclonal Antibody NPC-1C

External Source Codes: 
CAS Registry Number 1092658-06-4 (see NLM ChemIDplus info)
FDA UNII Code F988K568V2
PDQ Closed Trial Search ID 663436
PDQ Open Trial Search ID 663436 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C90532
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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