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Version: 17.06d (Release date: 2017-06-26)
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Trifluoperazine Hydrochloride (Code C904)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Trifluoperazine Hydrochloride

Definition: The hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects. Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium.

Label: Trifluoperazine Hydrochloride

NCI Thesaurus Code: C904 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0304381  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride
Eskazine
Jatroneural
SKF 5019
Stelazine
Terfluzine
Trifluoperazine Dihydrochloride
Trifluoperazine Hydrochloride
TRIFLUOPERAZINE HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 440-17-5 (see NLM ChemIDplus info)
FDA UNII Code 6P1Y2SNF5V
ChEBI ID CHEBI:9710 (see ChEBI info)
NSC Code 17474 (see NCI DTP info)
PDQ Closed Trial Search ID 40446
PDQ Open Trial Search ID 40446 (check for NCI PDQ open clinical trial info)
UMLS CUI C0304381

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H24F3N3S.2HCl
code C904
Contributing_Source FDA
Legacy_Concept_Name Trifluoperazine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C904

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