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Version: 17.06d (Release date: 2017-06-26)
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PI3Ka/mTOR Inhibitor PKI-179 (Code C90291)

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Terms & Properties

Preferred Name: PI3Ka/mTOR Inhibitor PKI-179

Definition: A second generation, small-molecule mimetic of ATP that targets the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. PKI-179 selectively inhibits mTOR and phosphoinositide-3-kinase (PI3K) alpha. By inhibiting the PI3K/mTOR signaling pathway, this agent may inhibit tumor cell proliferation and survival.

Label: PI3Ka/mTOR Inhibitor PKI-179

NCI Thesaurus Code: C90291 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2933673  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PI3Ka/mTOR Inhibitor PKI-179
PKI-179

External Source Codes: 
PDQ Closed Trial Search ID 658412
PDQ Open Trial Search ID 658412 (check for NCI PDQ open clinical trial info)
UMLS CUI C2933673

Other Properties:
     Name Value (qualifiers indented underneath)
code C90291
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90291

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