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Version: 17.06d (Release date: 2017-06-26)
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Tretinoin (Code C900)

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Terms & Properties

Preferred Name: Tretinoin

Definition: A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties.

NCI-GLOSS Definition: A nutrient that that body needs in small amounts to function and stay healthy. All-trans retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of all-trans retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). All-trans retinoic acid is being studied in the prevention and treatment of other types of cancer.

Display Name: Tretinoin

Label: Tretinoin

NCI Thesaurus Code: C900 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0040845  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid
2,4,6,8-Nonatetraenoic acid, 3, 7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-
Aberel
Airol
Aknoten
all-trans-Retinoic acid
all-trans-Vitamin A acid
all-trans retinoic acid
All-trans Retinoic Acid
All-trans Vitamin A Acid
all trans-Retinoic acid
ATRA
Avita
beta-Retinoic Acid
Cordes Vas
Dermairol
Epi-Aberel
Eudyna
Renova
Retin-A
Retin-A-Micro
Retin-A MICRO
Retinoic Acid
retinoic acid
Retisol-A
Ro 5488
Stieva-A
Stieva-A Forte
trans-Retinoic acid
trans-Retinoic Acid
Trans Retinoic Acid
Trans Vitamin A Acid
Tretinoin
TRETINOIN
tretinoin
Tretinoinum
Vesanoid
vitamin A acid
Vitamin A acid
Vitamin A Acid
Vitamin A acid, all-trans-
Vitinoin

External Source Codes: 
CAS Registry Number 302-79-4 (see NLM ChemIDplus info)
FDA UNII Code 5688UTC01R
ChEBI ID CHEBI:15367 (see ChEBI info)
NSC Code 122758 (see NCI DTP info)
PDQ Closed Trial Search ID 41258
PDQ Open Trial Search ID 41258 (check for NCI PDQ open clinical trial info)
UMLS CUI C0040845

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For (Oral) Acute promyelocytic leukemia (APL), characterized by the t(15;17) translocation or the PML/RARa gene refractory to or have relapsed from anthracycline chemotherapy, or for where anthracycline-based chemotherapy is contraindicated
Accepted_Therapeutic_Use_For (Topical) acne vulgaris; other dermatologic conditions; some skin cancers
Chemical_Formula C20H28O2
code C900
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Vitamin_A_Acid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C900

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