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Version: 17.06d (Release date: 2017-06-26)
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Chromomycin A3 (Code C895)

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Terms & Properties

Preferred Name: Chromomycin A3

Definition: A glycosidic antineoplastic antibiotic isolated from the bacterium Streptomyces griseus. Chromomycin A3 reversibly binds to guanine-cytosine (G-C) base pairs in the minor groove of DNA, thereby inhibiting RNA synthesis. This agent is used as a fluorescent chromosome dye. (NCI04)

Label: Chromomycin A3

NCI Thesaurus Code: C895 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0040563  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3B-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methylolivomycin D
Aburamycin B
Antibiotic 69895 A
Antibiotic B 599
Antibiotic from Streptomyces griseus
CHROMOMYCIN A3
Chromomycin A3
Olivomycin D, 3B-O-(4-O-acetyl-2, 6-dideoxy-3-C-methyl-.alpha.-L-arabino-hexopyranosyl)-7-methyl- (9CI)
Olivomycin D, 3B-O-(4-O-Acetyl-2, 6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methyl- (9CI)
Toyomycin
TOYOMYCIN

External Source Codes: 
CAS Registry Number 7059-24-7 (see NLM ChemIDplus info)
FDA UNII Code DVW027E7NL
ChEBI ID CHEBI:34638 (see ChEBI info)
NSC Code 58514 (see NCI DTP info)
PDQ Closed Trial Search ID 39184
PDQ Open Trial Search ID 39184 (check for NCI PDQ open clinical trial info)
UMLS CUI C0040563

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C57H82O26
code C895
Contributing_Source FDA
Legacy_Concept_Name Chromomycin_A3
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C895

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