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Version: 16.11d (Release date: 2016-11-28)
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Tobramycin Sulfate (Code C893)

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Terms & Properties

Preferred Name: Tobramycin Sulfate

Definition: The sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and fixes the 30 S-50 S ribosomal complex at the start codon (AUG), interfering with the initiation of protein synthesis. In addition, this agent induces misreading of the mRNA template, which results in 1) detachment of the ribosomal complex and inhibition of protein elongation or 2) incorporation of the incorrect amino acids into the growing polypeptide chain and the production of abnormal or nonfunctional proteins. Altogether, cell permeability is altered and cell death ensues.

Label: Tobramycin Sulfate

NCI Thesaurus Code: C893 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0701392  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
TOBRAMYCIN SULFATE
Tobramycin Sulfate
Tobrex

External Source Codes: 
CAS Registry Number 49842-07-1 (see NLM ChemIDplus info)
CAS Registry Number 79645-27-5 (see NLM ChemIDplus info)
FDA UNII Code HJT0RXD7JK
NSC Code 180514 (see NCI DTP info)
PDQ Closed Trial Search ID 39727
PDQ Open Trial Search ID 39727 (check for NCI PDQ open clinical trial info)
UMLS CUI C0701392

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula 2C18H37N5O9.5H2O4S
code C893
Contributing_Source FDA
Legacy_Concept_Name Tobramycin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C893

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