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Version: 16.11d (Release date: 2016-11-28)
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Tinidazole (Code C890)

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Terms & Properties

Preferred Name: Tinidazole

Definition: A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.

NCI-GLOSS Definition: A drug used to treat protozoal infections, such as amebiasis, giardiasis, and trichomoniasis. It belongs to a family of drugs called antiprotozoal agents. Tinidazole is also being evaluated in the treatment of Helicobacter pylori infections in people with low-grade gastric lymphoma.

Label: Tinidazole

NCI Thesaurus Code: C890 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0040263  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fasigyn
Simplotan
TDZ
Tindamax
TINIDAZOLE
Tinidazole
tinidazole

External Source Codes: 
CAS Registry Number 19387-91-8 (see NLM ChemIDplus info)
CAS Registry Number 25459-12-5 (see NLM ChemIDplus info)
FDA UNII Code 033KF7V46H
ChEBI ID CHEBI:63627 (see ChEBI info)
PDQ Closed Trial Search ID 43288
PDQ Open Trial Search ID 43288 (check for NCI PDQ open clinical trial info)
UMLS CUI C0040263

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C8H13N3O4S
code C890
Contributing_Source FDA
Legacy_Concept_Name Tinidazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C890

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