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Version: 17.06d (Release date: 2017-06-26)
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Levothyroxine Sodium (Code C888)

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Terms & Properties

Preferred Name: Levothyroxine Sodium

Definition: The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects.

Display Name: Levothyroxine Sodium

Label: Levothyroxine Sodium

NCI Thesaurus Code: C888 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0079691  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Levothyroxine Sodium
Levothyroxine sodium
LEVOTHYROXINE SODIUM
Sodium levothyroxine
Synthroid
Therapeutic Levothyroxine

External Source Codes: 
CAS Registry Number 25416-65-3 (see NLM ChemIDplus info)
FDA UNII Code 9J765S329G
NSC Code 36397 (see NCI DTP info)
PDQ Closed Trial Search ID 39117
PDQ Open Trial Search ID 39117 (check for NCI PDQ open clinical trial info)
UMLS CUI C0079691

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H10I4NO4.Na.H2O
code C888
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Therapeutic_Levothyroxine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C888

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