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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Thyroid-Stimulating Hormone (Code C887)

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Terms & Properties

Preferred Name: Recombinant Thyroid-Stimulating Hormone

Definition: A recombinant form of the heterodimeric human anterior pituitary glycoprotein thyroid-stimulating hormone (TSH) with potential use in hormone replacement therapy. Recombinant TSH binds to TSH receptors on thyroid epithelial cells and stimulates TSH-dependent signaling pathways. This stimulates iodine uptake and organification, and induces synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).

Label: Recombinant Thyroid-Stimulating Hormone

NCI Thesaurus Code: C887 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1535531  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Thyroid-Stimulating Hormone
Recombinant TSH
Thyroid Stimulating Hormone
THYROTROPIN
Thyrotropin
Thytropar

External Source Codes: 
CAS Registry Number 9002-71-5 (see NLM ChemIDplus info)
FDA UNII Code 02KSI6Z9AK
PDQ Closed Trial Search ID 526653
PDQ Open Trial Search ID 526653 (check for NCI PDQ open clinical trial info)
UMLS CUI C1535531

Other Properties:
     Name Value (qualifiers indented underneath)
code C887
Contributing_Source FDA
Legacy_Concept_Name Recombinant_Thyroid-Stimulating_Hormone
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C887

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