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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Thyroid-Stimulating Hormone (Code C887)

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Terms & Properties

Preferred Name: Recombinant Thyroid-Stimulating Hormone

Definition: A recombinant form of the heterodimeric human anterior pituitary glycoprotein thyroid-stimulating hormone (TSH) with potential use in hormone replacement therapy. Recombinant TSH binds to TSH receptors on thyroid epithelial cells and stimulates TSH-dependent signaling pathways. This stimulates iodine uptake and organification, and induces synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).

Label: Recombinant Thyroid-Stimulating Hormone

NCI Thesaurus Code: C887 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1535531  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Thyroid-Stimulating Hormone
Recombinant TSH
Thyroid Stimulating Hormone

External Source Codes: 
CAS Registry Number 9002-71-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 526653
PDQ Open Trial Search ID 526653 (check for NCI PDQ open clinical trial info)
UMLS CUI C1535531

Other Properties:
     Name Value (qualifiers indented underneath)
code C887
Contributing_Source FDA
Legacy_Concept_Name Recombinant_Thyroid-Stimulating_Hormone
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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