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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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FAK Inhibitor GSK2256098 (Code C88346)

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Terms & Properties

Preferred Name: FAK Inhibitor GSK2256098

Definition: A focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor GSK2256098 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thereby inhibiting tumor cell migration, proliferation and survival, and tumor angiogenesis. The tyrosine kinase FAK is normally activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated and constitutively activated in various tumor cell types.

Label: FAK Inhibitor GSK2256098

NCI Thesaurus Code: C88346 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981865  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FAK Inhibitor GSK2256098
Focal Adhesion Kinase Inhibitor GSK2256098

External Source Codes: 
PDQ Closed Trial Search ID 658411
PDQ Open Trial Search ID 658411 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981865

Other Properties:
     Name Value (qualifiers indented underneath)
code C88346
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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