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Version: 17.12d (Release date: 2017-12-26)
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Dopamine-Somatostatin Chimeric Molecule BIM-23A760 (Code C88345)

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Terms & Properties

Preferred Name: Dopamine-Somatostatin Chimeric Molecule BIM-23A760

Definition: A chimeric molecule directed against dopamine and somatostatin receptors with potential antineoplastic activity. Combining two pharmacological moieties, a somatostatin analogue and a dopamine agonist, dopamine-somatostatin chimeric molecule BIM-23A760 binds with high affinity to dopamine D2 receptor (D2R) and somatostatin receptor subtype 2 (SSTR2), and to a lesser extent to somatostatin receptor subtype 5 (SSTR5). This agent appears to exert its effect mainly by binding to D2R to activate the ERK1/2 and p38 MAPK pathways, thus inducing apoptosis and inhibiting cellular proliferation in non-functioning pituitary adenoma (NFPA) and neuroendocrine tumors. By binding to SSTR2, this agent may inhibit the secretion of growth hormone (GH) by the pituitary gland.

Label: Dopamine-Somatostatin Chimeric Molecule BIM-23A760

NCI Thesaurus Code: C88345 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2604387  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dopamine-Somatostatin Chimeric Molecule BIM-23A760

External Source Codes: 
CAS Registry Number 868562-36-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 661022
PDQ Open Trial Search ID 661022 (check for NCI PDQ open clinical trial info)
UMLS CUI C2604387

Other Properties:
     Name Value (qualifiers indented underneath)
code C88345
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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