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Version: 17.06d (Release date: 2017-06-26)
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Tetraphenyl Chlorin Disulfonate (Code C88344)

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Terms & Properties

Preferred Name: Tetraphenyl Chlorin Disulfonate

Definition: A meso-tetraphenylchlorin substituted by two adjacent sulfonated groups with potential photosensitizing activity. Upon administration, tetraphenyl chlorin disulfonate incorporates into the cell's endosome and lysosome membranes. Subsequently, cytotoxic agents are administered and accumulate in endosomal and lysosomal compartments; upon local activation by light, tetraphenyl chlorin disulfonate produces reactive oxygen species (ROS), such as singlet oxygen, damaging endo/lysosomal membranes and accumulated cytotoxic agents are released into the tumor cell cytosol. This photochemical internalization (PCI) method can enhance the efficacy and selectivity of cytotoxic agents.

Label: Tetraphenyl Chlorin Disulfonate

NCI Thesaurus Code: C88344 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413542  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Amphinex
Disulfonated Tetraphenylchlorin
Tetraphenyl Chlorin Disulfonate
TPCS2a

External Source Codes: 
PDQ Closed Trial Search ID 658036
PDQ Open Trial Search ID 658036 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413542

Other Properties:
     Name Value (qualifiers indented underneath)
code C88344
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88344

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