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Version: 17.06d (Release date: 2017-06-26)
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3'-Aminomethyl Nicotine-P. aeruginosa r-Exoprotein A Conjugate Vaccine (Code C88341)

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Terms & Properties

Preferred Name: 3'-Aminomethyl Nicotine-P. aeruginosa r-Exoprotein A Conjugate Vaccine

Definition: A hapten-carrier immunoconjugate composed of the hapten trans-3'-aminomethyl nicotine conjugated to a recombinant P. aeruginosa exoprotein A, rendered nontoxic through amino acid depletion, with potential immunostimulating activity. Upon vaccination with 3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine, the immune system may produce anti-nicotine antibodies. Antibody-bound nicotine cannot pass the blood brain barrier (BBB) to activate brain nicotine receptors. Nicotine, a small organic molecule that is not immunogenic, must be haptenized and conjugated to a carrier protein, such as nontoxic recombinant P. aeruginosa exoprotein A, to induce an antibody response. Aluminium hydroxide may be used as an adjuvant for this vaccine.

Display Name: 3'-Aminomethyl Nicotine-P. aeruginosa r-Exoprotein A Conjugate Vaccine

Label: 3'-Aminomethyl Nicotine-P. aeruginosa r-Exoprotein A Conjugate Vaccine

NCI Thesaurus Code: C88341 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981860  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3'-Aminomethyl Nicotine-P. aeruginosa r-Exoprotein A Conjugate Vaccine
Nicotine Conjugate Vaccine
NicVax

External Source Codes: 
PDQ Closed Trial Search ID 662744
PDQ Open Trial Search ID 662744 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981860

Other Properties:
     Name Value (qualifiers indented underneath)
code C88341
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88341

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