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Version: 16.11d (Release date: 2016-11-28)
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Vascular Disrupting Agent BNC105P (Code C88338)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Vascular Disrupting Agent BNC105P

Definition: A benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.

Display Name: Vascular Disrupting Agent BNC105P

Label: Vascular Disrupting Agent BNC105P

NCI Thesaurus Code: C88338 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981856  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BNC105P
Vascular Disrupting Agent BNC105P

External Source Codes: 
PDQ Closed Trial Search ID 662727
PDQ Open Trial Search ID 662727 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981856

Other Properties:
Name Value (qualifiers indented underneath)
code C88338
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88338

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