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Version: 17.06d (Release date: 2017-06-26)
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Smoothened Antagonist LDE225 Topical (Code C88337)

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Terms & Properties

Preferred Name: Smoothened Antagonist LDE225 Topical

Definition: A topical formulation of the small-molecule Smoothened (Smo) antagonist LDE225 with potential antineoplastic activity. Upon topical application, smoothened antagonist LDE225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo.

Label: Smoothened Antagonist LDE225 Topical

NCI Thesaurus Code: C88337 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413601  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LDE225
Smoothened Antagonist LDE225 Topical

External Source Codes: 
PDQ Closed Trial Search ID 662542
PDQ Open Trial Search ID 662542 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413601

Other Properties:
     Name Value (qualifiers indented underneath)
code C88337
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88337

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