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Version: 17.06d (Release date: 2017-06-26)
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Archexin (Code C88335)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Archexin

Definition: A 20-mer antisense oligodeoxynucleotide (ODN) against the proto-oncogene Akt with potential antineoplastic activity. Akt-1 antisense oligonucleotide RX-0201 binds to Akt-1 mRNA, inhibiting translation of the transcript; suppression of Akt-1 expression may result in the inhibition of cellular proliferation and the induction of apoptosis in tumor cells that overexpress Akt-1. Akt-1 is a serine-threonine protein kinase that stimulates proliferation and inhibits apoptosis of tumor cells.

Label: Archexin

NCI Thesaurus Code: C88335 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413599  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Akt-1 Antisense Oligonucleotide RX-0201
Archexin
ARCHEXIN
RX-0201

External Source Codes: 
FDA UNII Code 4TEW51C830
PDQ Closed Trial Search ID 662321
PDQ Open Trial Search ID 662321 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413599

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C194H228N70O103P19S19
code C88335
Contributing_Source FDA
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88335

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