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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Gamma-Secretase Inhibitor RO4929097 (Code C88333)

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Terms & Properties

Preferred Name: Gamma-Secretase Inhibitor RO4929097

Definition: An orally bioavailable, small-molecule gamma secretase (GS) inhibitorwith potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks certain enzymes that are needed for cell growth. This may slow the growth of cancer cells. It may also decrease the growth of new blood vessels that tumors need to grow. It is a type of gamma-secretase inhibitor and a type of Notch signaling inhibitor.

Display Name: Gamma-Secretase Inhibitor RO4929097

Label: Gamma-Secretase Inhibitor RO4929097

NCI Thesaurus Code: C88333 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2742210  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gamma-Secretase Inhibitor RO4929097

External Source Codes: 
PDQ Closed Trial Search ID 662240
PDQ Open Trial Search ID 662240 (check for NCI PDQ open clinical trial info)
UMLS CUI C2742210

Other Properties:
     Name Value (qualifiers indented underneath)
code C88333
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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