|Gamma-Secretase Inhibitor RO4929097 (Code C88333)|
|Terms & Properties|
Preferred Name: Gamma-Secretase Inhibitor RO4929097
Definition: An orally bioavailable, small-molecule gamma secretase (GS) inhibitorwith potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth.
NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks certain enzymes that are needed for cell growth. This may slow the growth of cancer cells. It may also decrease the growth of new blood vessels that tumors need to grow. It is a type of gamma-secretase inhibitor and a type of Notch signaling inhibitor.
Display Name: Gamma-Secretase Inhibitor RO4929097
Label: Gamma-Secretase Inhibitor RO4929097
NCI Metathesaurus Link: C2742210 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
|Gamma-Secretase Inhibitor RO4929097|
External Source Codes:
|PDQ Closed Trial Search ID||662240|
|PDQ Open Trial Search ID||662240 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|