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Version: 16.11d (Release date: 2016-11-28)
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Ad5-yCD/mutTK(SR39)rep-ADP (Code C88330)

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Terms & Properties

Preferred Name: Ad5-yCD/mutTK(SR39)rep-ADP

Definition: A second generation, replication-competent adenovirus type 5 containing a yeast cytosine deaminase(yCD)/mutant sr39 herpes simplex virus thymidine kinase fusion (yCD/mutTKsr39) gene and the 11.6 kDa adenovirus death protein (ADP) gene with potential oncolytic activity. Upon intratumoral administration and transduction of Ad5-yCD/mutTK(SR39)rep-ADP into tumor cells and subsequent expression of cytosine deaminase and viral thymidine kinase, administered prodrugs 5-fluorocytosine (5-FC) and ganciclovir are converted into their respective metabolites 5-fluorouracil (5-FU) and ganciclovir-5-monophosphate (ganciclovir-MP); 5-FU is subsequently metabolized to cytotoxic active metabolites 5-fluoroxyuridine monophosphate (F-UMP) and 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP); ganciclovir-TP subsequently is converted by mammalian thymidine kinase to cytotoxic ganciclovir-triphosphate (ganciclovir -TP). Tumor cells adjacent to tumor cells transduced with this agent may be killed through a 'bystander effect'. ADP may enhance spread and oncolytic activity of replication-competent adenoviruses. In addition to its oncolytic activity, Ad5-yCD/mutTK(SR39)rep-ADP may exhibit radiosensitizing activity.

Display Name: Ad5-yCD/mutTK(SR39)rep-ADP

Label: Ad5-yCD/mutTK(SR39)rep-ADP

NCI Thesaurus Code: C88330 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413593  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad5-yCD/mutTK(SR39)rep-ADP

External Source Codes: 
PDQ Closed Trial Search ID 662126
PDQ Open Trial Search ID 662126 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413593

Other Properties:
Name Value (qualifiers indented underneath)
code C88330
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88330

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