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Version: 17.12d (Release date: 2017-12-26)
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Litronesib (Code C88328)

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Terms & Properties

Preferred Name: Litronesib

Definition: An inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein that plays an essential role during mitosis, particularly in the regulation of spindle dynamics, including assembly and maintenance.

Display Name: Litronesib

Label: Litronesib

NCI Thesaurus Code: C88328 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981845  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Propanamide, N-[4-(2,2-dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl] amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-, (-)-

External Source Codes: 
CAS Registry Number 910634-41-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 661443
PDQ Open Trial Search ID 661443 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981845

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H37N5O4S2
code C88328
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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