skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Anti-IL-1 alpha Monoclonal Antibody MABp1 (Code C88325)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Anti-IL-1 alpha Monoclonal Antibody MABp1

Definition: A human IgG1 monoclonal antibody directed against interleukin-1 alpha (IL1a) with potential A human IgG1 monoclonal antibody targeting the inflammatory cytokine interleukin-1 alpha (IL1a) with potential antineoplastic, anti-cachectic and anti-angiogenic activities. Anti-IL1a monoclonal antibody MABp1 targets and binds to IL1a and prevents IL1a activity. This prevents IL1a-mediated tumorigenesis and angiogenesis. In addition, MABp1 abrogates IL1a-mediated cachexia. IL1a, an inflammatory mediator expressed on monocytes, platelets and overexpressed by certain tumors, plays a key role in the promotion of tumor cell growth, metastasis and invasion. In addition, IL1a stimulates metabolic activity in the central nervous system.

Display Name: Anti-IL-1 alpha Monoclonal Antibody MABp1

Label: Anti-IL-1 alpha Monoclonal Antibody MABp1

NCI Thesaurus Code: C88325 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3896706  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-IL-1 Alpha Monoclonal Antibody
Anti-IL-1 alpha Monoclonal Antibody MABp1
Anti-IL1a Monoclonal Antibody
MABp1
Xilonix

External Source Codes: 
PDQ Closed Trial Search ID 661044
PDQ Open Trial Search ID 661044 (check for NCI PDQ open clinical trial info)
UMLS CUI C3896706

Other Properties:
     Name Value (qualifiers indented underneath)
code C88325
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88325

Mainbox Bottom