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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Anti-IL-1 alpha Monoclonal Antibody MABp1 (Code C88325)

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Terms & Properties

Preferred Name: Anti-IL-1 alpha Monoclonal Antibody MABp1

Definition: A human IgG1 monoclonal antibody directed against interleukin-1 alpha (IL1a) with potential A human IgG1 monoclonal antibody targeting the inflammatory cytokine interleukin-1 alpha (IL1a) with potential antineoplastic, anti-cachectic and anti-angiogenic activities. Anti-IL1a monoclonal antibody MABp1 targets and binds to IL1a and prevents IL1a activity. This prevents IL1a-mediated tumorigenesis and angiogenesis. In addition, MABp1 abrogates IL1a-mediated cachexia. IL1a, an inflammatory mediator expressed on monocytes, platelets and overexpressed by certain tumors, plays a key role in the promotion of tumor cell growth, metastasis and invasion. In addition, IL1a stimulates metabolic activity in the central nervous system.

Display Name: Anti-IL-1 alpha Monoclonal Antibody MABp1

Label: Anti-IL-1 alpha Monoclonal Antibody MABp1

NCI Thesaurus Code: C88325 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3896706  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-IL-1 Alpha Monoclonal Antibody
Anti-IL-1 alpha Monoclonal Antibody MABp1
Anti-IL1a Monoclonal Antibody

External Source Codes: 
PDQ Closed Trial Search ID 661044
PDQ Open Trial Search ID 661044 (check for NCI PDQ open clinical trial info)
UMLS CUI C3896706

Other Properties:
     Name Value (qualifiers indented underneath)
code C88325
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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