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Version: 17.08d (Release date: 2017-08-28)
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Factor VIIa Inhibitor PCI-27483 (Code C88324)

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Terms & Properties

Preferred Name: Factor VIIa Inhibitor PCI-27483

Definition: A reversible small-molecule inhibitor of activated factor VII (factor VIIa) with potential antineoplastic and antithrombotic activities. FVII, a serine protease, becomes activated (FVIIa) upon binding with TF forming the FVIIa/TF complex, which induces intracellular signaling pathways by activating protease activated receptor 2 (PAR-2). Upon subcutaneous administration, factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex, which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways, thereby inhibiting tumor cell proliferation, angiogenesis, and metastasis of TF-overexpressing tumor cells. In addition, this agent inhibits both the extrinsic and intrinsic coagulation cascades, preventing blood clot formation. TF, a blood protein overexpressed on the cell surface of a variety of tumor cell types, may correlate with poor prognosis; PAR-2 (also known as thrombin receptor-like 1) is a G protein-coupled receptor (GPCR) and a protease-activated receptor.

Label: Factor VIIa Inhibitor PCI-27483

NCI Thesaurus Code: C88324 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413585  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Factor VIIa Inhibitor PCI-27483

External Source Codes: 
PDQ Closed Trial Search ID 661024
PDQ Open Trial Search ID 661024 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C88324
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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