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Version: 17.08d (Release date: 2017-08-28)
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Fumagillin-Derived Polymer Conjugate XMT-1107 (Code C88321)

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Terms & Properties

Preferred Name: Fumagillin-Derived Polymer Conjugate XMT-1107

Definition: A polymeric prodrug consisting of the fumagillol-derived small molecule XMT-1191 tethered to the hydrophilic, biodegradable70 kDa polymer poly[1-hydroxymethylethylene hydroxymethylformal] (PHF) with potential antiangiogenic and antineoplastic activities. Upon administration, fumagillin-derived polymer conjugate XMT-1107 releases XMT-1191, which may inhibit angiogenesis through the irreversible inhibition of the methionine aminopeptidase 2 (METAP2); although the exact mechanism of action has yet to be fully elucidated, this agent appears to induce cell cycle arrest in endothelial cells, inhibiting their proliferation and migration. Compared to an unconjugated fumagillin analog, XMT-1107 exhibits improved solubility and an extended half life due to its PHF backbone. METAP2, a member of the methionyl aminopeptidase family, binds two cobalt or manganese ions and protects the alpha subunit of eukaryotic initiation factor 2 (EIF2) from inhibitory phosphorylation by removing the amino-terminal methionine residue from nascent protein; this aminopeptidase may be overexpressed in a variety of tumor cell types.

Display Name: Fumagillin-Derived Polymer Conjugate XMT-1107

Label: Fumagillin-Derived Polymer Conjugate XMT-1107

NCI Thesaurus Code: C88321 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413581  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fumagillin-Derived Polymer Conjugate XMT-1107

External Source Codes: 
PDQ Closed Trial Search ID 660895
PDQ Open Trial Search ID 660895 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C88321
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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