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Version: 17.06d (Release date: 2017-06-26)
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Iodine I-123 ADAM (Code C88319)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Iodine I-123 ADAM

Definition: A radiopharmaceutical containing the serotonin transporter (SERT) ligand ADAM [2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine] labeled with the radioisotope iodine I 123, with SERT-binding and radioisotope activities. Upon administration, iodine I 123 ADAM selectively binds to SERT-expressing cells; subsequently, SERT-expressing tissues may be visualized using single photon emission computed tomography (SPECT). SERT is a monamine transporter protein found in the membranes of neurons and platelets; in neurons it transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons, terminating serotonin's function.

Display Name: Iodine I-123 ADAM

Label: Iodine I-123 ADAM

NCI Thesaurus Code: C88319 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413579  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ADAM I-123
Iodine-123-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine
Iodine I-123 ADAM

External Source Codes: 
CAS Registry Number 305352-16-3 (see NLM ChemIDplus info)
FDA UNII Code 20LJC2LC2J
PDQ Closed Trial Search ID 660864
PDQ Open Trial Search ID 660864 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413579

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H17IN2S
code C88319
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88319

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