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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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HER2Bi-Armed Activated T Cells (Code C88317)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: HER2Bi-Armed Activated T Cells

Definition: Activated T cells (ATC) that have been coated with bispecific antibodies (BiAb), with potential antineoplastic and immunomodulating activities. In vitro, T cells are activated through exposure to the anti-CD3 murine monoclonal antibody OKT3 and interleukin 2 for 14 days and then armed with anti-CD3 x anti-Her2 bispecific antibody (Her2Bi). Upon administration, HER2Bi-armed activated T cells attach to CD3-expressing T cells and HER2/neu-expressing tumor cells, selectively cross-linking T cells and tumor cells; this may result in the recruitment and activation of cytotoxic T lymphocyte (CTLs), CTL perforin-mediated tumor cell cytolysis, and the secretion of antitumor cytokines and chemokines.

Display Name: HER2Bi-Armed Activated T Cells

Label: HER2Bi-Armed Activated T Cells

NCI Thesaurus Code: C88317 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413578  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD3 x Anti-Her2/neu Bispecific Antibody-Armed Activated T Cells
HER2Bi-Armed Activated T Cells
HER2Bi-Armed ATCs

External Source Codes: 
PDQ Closed Trial Search ID 660810
PDQ Open Trial Search ID 660810 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C88317
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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