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Version: 16.11d (Release date: 2016-11-28)
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CDC7 Kinase Inhibitor NMS-1116354 (Code C88316)

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Terms & Properties

Preferred Name: CDC7 Kinase Inhibitor NMS-1116354

Definition: An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor NMS-1116354 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 initiates DNA replication by phosphorylating MCM2 (minichromosome maintenance complex component 2) at Ser40 and Ser53.

Display Name: CDC7 Kinase Inhibitor NMS-1116354

Label: CDC7 Kinase Inhibitor NMS-1116354

NCI Thesaurus Code: C88316 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413571  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CDC7 Kinase Inhibitor NMS-1116354
NMS-1116354

External Source Codes: 
PDQ Closed Trial Search ID 660731
PDQ Open Trial Search ID 660731 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413571

Other Properties:
Name Value (qualifiers indented underneath)
code C88316
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88316

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