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National Cancer Institute
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Version: 17.10e (Release date: 2017-10-30)
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Tepotinib (Code C88314)

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Terms & Properties

Preferred Name: Tepotinib

Definition: An inhibitor of MET tyrosine kinase with potential antineoplastic activity. Tepotinib selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated in many tumor cell types; this protein plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.

Display Name: Tepotinib

Label: Tepotinib

NCI Thesaurus Code: C88314 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3658472  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzonitrile, 3-(1,6-Dihydro-1-((3-(5-((1-methyl-4-piperidinyl)methoxy)-2-pyrimidinyl)phenyl)methyl)-6-oxo-3-pyridazinyl)-
EMD 1214063

External Source Codes: 
CAS Registry Number 1100598-32-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 660212
PDQ Open Trial Search ID 660212 (check for NCI PDQ open clinical trial info)
UMLS CUI C3658472

Other Properties:
     Name Value (qualifiers indented underneath)
code C88314
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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