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Version: 17.06d (Release date: 2017-06-26)
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Momelotinib (Code C88311)

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Terms & Properties

Preferred Name: Momelotinib

Definition: An orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with potential antineoplastic activity. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders; the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617. The JAK-STAT signaling pathway is a major mediator of cytokine activity and is often dysregulated in a variety of tumor cell types.

Display Name: Momelotinib

Label: Momelotinib

NCI Thesaurus Code: C88311 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2744845  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CYT387
GS-0387
Momelotinib
MOMELOTINIB
N-(Cyanomethyl)-4-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)benzamide

External Source Codes: 
CAS Registry Number 1056634-68-4 (see NLM ChemIDplus info)
FDA UNII Code 6O01GMS00P
PDQ Closed Trial Search ID 660135
PDQ Open Trial Search ID 660135 (check for NCI PDQ open clinical trial info)
UMLS CUI C2744845

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H22N6O2
code C88311
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88311

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