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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes (Code C88310)

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Terms & Properties

Preferred Name: Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes

Definition: A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to cytomegalovirus (CMV) and adenovirus (AdV) with potential antiviral activity. Allogeneic CMV/AdV-specific cytotoxic T lymphocytes are prepared by exposing donor-derived CTLs to a lethally irradiated Epstein-Barr virus-positive lymphoblastoid B cell line (EBV-LCL) that has been transduced with a clinical-grade adenoviral vector (Ad5f35CMVpp65) as a source of CMV and AdV antigens. Infusion of these CTLs into stem cell transplant recipients may prevent CMV and AdV viral disease.

Display Name: Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes

Label: Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes

NCI Thesaurus Code: C88310 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413565  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 660070
PDQ Open Trial Search ID 660070 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C88310
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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