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Version: 17.06d (Release date: 2017-06-26)
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Tasisulam Sodium (Code C88304)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tasisulam Sodium

Definition: The sodium salt of an acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity.

Display Name: Tasisulam Sodium

Label: Tasisulam Sodium

NCI Thesaurus Code: C88304 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3537265  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzamide, N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichloro-, Sodium Salt
Tasisulam Sodium

External Source Codes: 
CAS Registry Number 519055-63-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 506118
PDQ Open Trial Search ID 506118 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 18949427 (see PubMed Primary Reference info)
UMLS CUI C3537265

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C11H5BrCl2NO3S2.Na
code C88304
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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